Myotonic dystrophy (DM) includes two major types — DM1 and DM2 — both caused by genetic defects. They result in multisystem disorders characterized by skeletal muscle weakness and myotonia (difficulty relaxing muscles after use), cardiac abnormalities, cataracts, and other abnormalities. DM1, the most common type, results from an abnormal DNA expansion in the DMPK gene on chromosome 19
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2.4 Screening for type 1 diabetes risk with a panel of islet autoantibodies is currently recommended in the setting of a research trial or can be offered as an option for first-degree family members of a proband with type 1 diabetes. B. 2.5 Persistence of autoantibodies is a risk factor for clinical diabetes and may serve as an indication for More than 133 million Americans have diabetes or prediabetes. 1. As of 2019, 37.3 million people—or 11.3% of the U.S. population—had diabetes. 1 More than 1 in 4 people over the age of 65 had diabetes. Nearly 1 in 4 adults with diabetes didn’t know they had the disease. 2. About 90% to 95% of diabetes cases are type 2 diabetes. 3
Codes. E08 Diabetes mellitus due to underlying condition. E09 Drug or chemical induced diabetes mellitus. E10 Type 1 diabetes mellitus. E11 Type 2 diabetes mellitus. E13 Other specified diabetes mellitus. E00-E89. ICD-10-CM Range E00-E89. Endocrine, nutritional and metabolic diseases.
An insulin or C-peptide level below 5 µU/mL (0.6 ng/mL) suggests type 1 DM; a fasting C-peptide level greater than 1 ng/dL in a patient who has had diabetes for more than 1-2 years is suggestive of type 2 (ie, residual beta-cell function).

Type 1 is defined by the loss of insulin production by the pancreas and type 2 is defined by loss of peripheral responses to insulin. If left untreated type 1 diabetes can lead to fatal ketoacidosis. Of the two major forms of diabetes mellitus, type 2 represents the prevalent form of the disease.

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    • dm 1 vs dm 2